Di-tert-butyl dicarbonate

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Aha ngwaahịa:Di-tert-butyl dicarbonate

Ụdị okwu:(BOC)2O;(BOC)2O FLUKA;BOC;BOC ANHYDRIDE;tert-butyldicarbonate;PYROCARBONIC ACID DI-TERT-BUTYL ESTER;RARECHEM TB OC 0001;Boc Anhydride, siri ike/mmiri mmiri.

CAS:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Ụdị ngwaahịa:Ndị na-ahụ maka ọgwụ; Mmalite Raw Materials & Intermediates; Amino Acid Mmepụta; Organics; N-Chebe Reagents; Biochemistry; Peptide Synthesis; Nchekwa & Mmepụta Reagents (maka Synthesis); Ndị na-echebe Reagents (Peptide Synthesis); Rechart maka Oligos; Usoro Boc-Amino acid; Reagents dị iche iche; DIBOC; 1H-Inden-1-ol; bc0001; 24424-99-5

Faịlụ Mol:24424-99-5.mol

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Njirimara kemịkalụ Di-tert-butyl dicarbonate

Ebe mgbaze	23 Celsius C (ọkụ ọkụ)
Ebe esi nri	56-57 Celsius C/0.5 mmHg (ọkụ.)
njupụta	0.95 g/mL na 25 Celsius C (ọkụ)
uzuoku mgbali	3.85Pa na 25 ℃
index refractive	n20/D 1.409 (ọkụ)
Fp	99 Celsius F
nchekwa okpomọkụ.	2-8 Celsius C
ụdị	Crystalline siri ike na-agbaze dị ala
agba	Ọcha
Nnukwu ike ndọda	0,950
Mmiri Solubility	Enwere ike iji decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile na dimethylformamide.Na-enweghị atụ na mmiri.
Mmetụta	Mmiri nwere mmetụta
BRN	1911173
InChiKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 na 25 ℃
Ntuziaka dataBase CAS	24424-99-5(CAS DataBase ntụaka)
Sistemụ ndekọ ihe EPA	Dicarbonic acid, bis (1,1-dimethylethyl) ester (24424-99-5)

Ozi nchekwa

Koodu egwu	T+,T,F,X,F+
Nkwupụta ihe egwu	11-19-26-36/37/38-43-10-40
Nkwupụta nchekwa	16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
RIDADR	UN 2929 6.1/PG 1
WGK Germany	3
RTECS	HT0230000
F	4.4-10-21
Okpomọkụ akpaaka	460 Celsius C
Ihe edeturu egwu	Nke na-enwu ọkụ/Na-ewe iwe/Na-egbu egbu
TSCA	Ee
Klas Hazard	6.1
Otu ngwugwu	I
Koodu HS	29209010
Nsi	LD50 ọnụ na oke bekee:> 5000 mg / kg LD50 dermal oke bekee> 2000 mg / kg

Di-tert-butyl dicarbonate Ojiji na Synthesis

Njirimara kemịkalụ	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) bụ ihe na-enweghị agba na kristal na-acha ọcha ma ọ bụ edo edo, oke siri ike ma ọ bụ mmiri mmiri doro anya.Ọ na-agbaze gburugburu ụlọ okpomọkụ (mp=23 ° C).Ọ naghị ere ere na nke a ma ọ bụ ọbụna obere okpomọkụ dị elu.Dịka ọmụmaatụ, a na-asachapụ ya nke ọma site na mgbaze n'okpuru mbelata nrụgide na okpomọkụ ruo ihe dịka 65 Celsius.N'ebe okpomọkụ dị elu, ọ ga-agbaze na isobutene, t-butyl mmanya na carbon dioxide.
Na-eji	Di-tert-butyl dicarbonate (Boc2O) bụ reagent a na-ejikarị eme ihe maka iwebata ndị otu nchekwa na njikọ peptide.Ọ na-arụ ọrụ dị mkpa na nkwadebe nke 6-acetyl-1,2,3,4-tetrahydropyridine site na imeghachi omume na 2-piperidone.Ọ na-eje ozi dị ka otu nchebe na-eji na siri ike na-adọ peptide njikọ.
Nkwadebe	Nkwadebe nke Di-tert-butyl dicarbonate bụ ndị a: N'ime monoester sodium nnu ngwọta agbakwunyere 2g N, N-dimethylformamide, 1g nke pyridine, 1g nke triethylamine, Cooling na -5 ~ 0 ° C, 60g diphosgene ji nwayọọ nwayọọ. agbakwunyere dropwise n'ime 1.5h dropwise mgbakwunye zuru oke, kpoo ọkụ n'ime ụlọ (25 Celsius C), etinyere ya maka awa 2, a na-ahapụ mmeghachi omume ahụ ka ọ guzoro mgbe nzacha, na-asa ihe ngwọta organic.Mịrị na magnesium sulfate na-ekpo ọkụ, ihe mgbaze na-ekpochapụ na nrụgide ikuku iji nye ngwaahịa crude 65 ~ 70g.Mgbe jụrụ oyi na crystallization, 57-60g nke di-tert-butyl dicarbonate nwetara na mkpụrụ nke 60-63%.
Nkọwa	ChEBI: Di-tert-butyl dicarbonate bụ acyclic carboxylic anhydride.Ọ na-arụ ọrụ metụtara dicarbonic acid.
Mmeghachi omume	Mmeghachi omume nke anilines dochie anya na Boc2O na ọnụnọ nke stoichiometric ego nke 4-dimethylaminopyridine (DMAP) na ihe mgbaze inert (acetonitrile, dichloromethane, ethyl acetate, tetrahydrofuran, toluene) na ụlọ okpomọkụ na-eduga na aryl isocyanates na ihe fọrọ nke nta ka ọ bụrụ n'ime ọnụ ọgụgụ. min. Di-tert-butyl dicarbonate na 4- (dimethylamino) pyridine legharịrị.Mmeghachi omume ha na amines na alcohols
Nkọwa zuru oke	Di-tert-butyl dicarbonate (Boc₂O) bụ reagent a na-ejikarị maka iwebata otu nchebe Boc na ọrụ amine.A na-ejikwa ya dị ka ihe na-eme ka mmiri na-ekpo ọkụ na ụfọdụ mmeghachi omume organic, karịsịa na acid carboxylic, ụfọdụ hydroxyl otu, ma ọ bụ nwere nitroalkanes bụ isi.
Hazard	Ihe mgbakasị ahụ nwere ike ịkpata mmerụ anya dị njọ;Nwere ike ịkpata mmetụta anụ ahụ;Na-egbu egbu nke ukwuu site na ikuku ume
Ịkụ ọkụ na mpụpụ	Enwere ike ire ọkụ
Ụzọ nke ịdị ọcha	Gbazee ester site na kpo oku na ~ 35o, ma gbanye ya na oghere.Ọ bụrụ na IR na NMR (1810m 1765 cm-1, na CCl4 1.50 singlet) na-atụ aro ka ọ ghara ịdị ọcha, wee sachaa ya na nha nha nha nke H2O nwere citric acid iji mee ka oyi akwa dị ntakịrị acidic, na-anakọta oyi akwa ma kpoo ya n'elu MgSO4. ma tụba ya na oghere.[Pope et al.Org Synth 57 45 1977, Keller et al.Org Synth 63 160 1985, Grehn et al.Angew Chem 97 519 1985.] NA-ACHỤRỤ AFỌ.