Ngwaahịa
N-Methyl-2-pyrrolidone
Njirimara Chemical Pyrrolidone
| Ebe mgbaze | -24C (ọkụ ọkụ) |
| Ebe esi nri | 202 Celsius (ọkụ) 81-82 Celsius C/10 mmHg (ọkụ.) |
| njupụta | 1.028 g/mL na 25 Celsius C (ọkụ) |
| uzuoku njupụta | 3.4 (na ikuku) |
| uzuoku mgbali | 0.29 mm Hg (20 Celsius C) |
| index refractive | n20/D 1.479 |
| Fp | 187 Celsius F |
| nchekwa okpomọkụ. | Na-echekwa na +5°C ruo +30°C. |
| solubility | ethanol: miscible0.1ML/ml, doro anya, enweghị agba (10%, v/v) |
| ụdị | Mmiri mmiri |
| pka | -0.41±0.20 (buru amụma) |
| agba | ≤20 (APHA) |
| PH | 8.5-10.0 (100g/l, H2O, 20 ℃) |
| Isi | Obere amine isi |
| Ọnụ ego PH | 7.7-8.0 |
| mgbawa ịgba | 1.3-9.5% (V) |
| Mmiri Solubility | > = 10 g / 100 ml na 20 ºC |
| Mmetụta | Hygroscopic |
| kacha | 283nm (MeOH) (ọkụ) |
| Merck | 14,6117 |
| BRN | 106420 |
| Nkwụsi ike: | Kwụsie ike, mana ọ na-erekasị mgbe ọkụ kpughee.Enwere ike ịgbanwu ọkụ.Na-ekwekọghị na ihe ndị na-emepụta oxidizing siri ike, acid siri ike, ndị na-ebelata ihe, ntọala. |
| InChiKey | SECXISVLQFMRJM-UHFFFAOYSA-N |
| LogP | -0.46 na 25 ℃ |
| Ntuziaka dataBase CAS | 872-50-4(CAS DataBase ntụaka) |
| Ntuziaka Chemistry NIST | 2-Pyrrolidinone, 1-methyl-(872-50-4) |
| Sistemụ ndekọ ihe EPA | N-Methyl-2-pyrrolidone (872-50-4) |
Ozi nchekwa
| Koodu egwu | T, Xi |
| Nkwupụta ihe egwu | 45-65-36/38-36/37/38-61-10-46 |
| Nkwupụta nchekwa | 41-45-53-62-26 |
| WGK Germany | 1 |
| RTECS | UY579000 |
| F | 3-8-10 |
| Okpomọkụ akpaaka | 518 Celsius F |
| TSCA | Y |
| Koodu HS | 2933199090 |
| Data ihe dị ize ndụ | 872-50-4(Data ihe dị ize ndụ) |
| Nsi | LD50 ọnụ na oke bekee: 3598 mg / kg LD50 dermal Rabbit 8000 mg / kg |
Ojiji Pyrrolidone na Synthesis
| Njirimara kemịkalụ | N-Methyl-2-pyrrolidone bụ mmiri mmiri na-acha odo odo na-enweghị ụcha nke nwere ntakịrị isi amonia.N-Methyl-2-pyrrolidone bụ ihe na-adịghị mma na mmiri.Ọ bụ nke ukwuu soluble na ala alcohols, ala ketones, ether, ethyl acetate, chloroform, na benzene na moderate soluble na aliphatic hydrocarbons.N-Methyl-2-pyrrolidone siri ike hygroscopic, kemịkalụ kwụsiri ike, ọ bụghị ihe na-emebi emebi n'akụkụ carbon steel na aluminom, yana obere ihe na-emebi emebi na ọla kọpa.Ọ nwere nrapado dị ala, kemịkalụ siri ike na nkwụsi ike ọkụ, nnukwu polarity, na obere mgbanwe.Ngwaahịa a dị ntakịrị na-egbu egbu, yana oke itinye uche ya na ikuku bụ 100ppm.
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| Na-eji |
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| nsi | Ọnụ (mus) LD50:5130 mg/kg; Oral (oke) LD50:3914 mg/kg; Dermal (rbt) LD50:8000 mg/kg. |
| Mkpofu mkpofu | Kpọtụrụ steeti, mpaghara ma ọ bụ iwu obodo maka mkpofu kwesịrị ekwesị.A ga-emerịrị mkpofu dịka iwu gọọmentị siri dị.Mmiri, ma ọ bụrụ na ọ dị mkpa na ndị na-ehicha ihe. |
| nchekwa | N-Methyl-2-pyrrolidone bụ hygroscopic (na-eburu mmiri mmiri) mana kwụsiri ike n'okpuru ọnọdụ nkịtị.Ọ ga-eji ike oxidizers ike dị ka hydrogen peroxide, nitric acid, sulfuric acid, wdg. The isi ire ere ngwaahịa na-emepụta carbon monoxide na nitrogen oxide uzuzu.Ekwesịrị izere ikpughe oke ma ọ bụ mwụfu dị ka ihe omume dị mma.Ụlọ ọrụ Lyondell Chemical na-atụ aro iyi uwe butyl mgbe ị na-eji N-Methyl-2-pyrrolidone.Ekwesịrị ịchekwa N-Methyl-2-pyrrolidone n'ime igwe dị nro dị nro ma ọ bụ phenolic dị ọcha.Egosipụtara Teflon®1 na Kalrez®1 ka ha bụrụ akụrụngwa gasket dabara adaba.Biko lelee MSDS tupu ejizi ya. |
| Nkọwa | N-Methyl-2-pyrrolidone bụ ihe mgbaze aprotic nwere ngwa dị iche iche: nhazi petrochemical, mkpuchi elu, akwa na pigmenti, ogige ihicha ụlọ na ụlọ, yana usoro ọrụ ugbo na ọgwụ.Ọ na-abụkarị ihe mgbakasị ahụ, mana o mewokwa ka ọtụtụ ọnọdụ kọntaktị dermatitis na obere ụlọ ọrụ electrotechnical. |
| Njirimara kemịkalụ | N-Methyl-2-pyrrolidone bụ mmiri mmiri na-enweghị agba ma ọ bụ na-acha odo odo nwere isi amine.Ọ nwere ike nweta ọtụtụ mmeghachi omume kemịkalụ n'agbanyeghị na anabatara ya dị ka ihe mgbaze kwụsiri ike.Ọ na-eguzogide hydrolysis n'okpuru ọnọdụ nnọpụiche, mana acid siri ike ma ọ bụ ọgwụgwọ ntọala na-ebute mgbanaka oghere na 4-methyl aminobutyric acid.N-Methyl-2-pyrrolidone nwere ike belata ka ọ bụrụ 1-methyl pyrrolidine na borohydride.Ọgwụgwọ na ọgwụ chlorinating na-ebute nguzobe amide, nke dị n'etiti nke nwere ike dochie ya ọzọ, ebe ọgwụgwọ na amyl nitrate na-emepụta nitrate.Enwere ike ịgbakwunye Olefins na ọnọdụ 3 site na ọgwụgwọ mbụ na oxalic esters, wee jiri aldehyes kwesịrị ekwesị (Hort na Anderson 1982). |
| Na-eji | N-Methyl-2-pyrrolidone bụ ihe mgbaze pola nke a na-eji na kemịkalụ organic na kemịkalụ polymer.Ngwa ngwa buru ibu gụnyere mgbake na ịdị ọcha nke acetylenes, olefins, na diolefins, nchacha gas, na mmịpụta aromatics sitere na feedstocks.N-Methyl-2-pyrrolidone bụ ihe mgbaze ụlọ ọrụ na-agbanwe agbanwe.A kwadoro NMP ugbu a maka iji naanị na ọgwụ ọgwụ anụmanụ.Mkpebi nke ọnọdụ na metabolism nke NMP na oke ga-atụnye aka n'ịghọta toxicology nke kemịkalụ a na-apụ apụ nke mmadụ nwere ike ikpughe na ya na-abawanye ụba. |
| Na-eji | Ihe mgbaze maka resins okpomọkụ dị elu;nhazi petrochemical, na ụlọ ọrụ mmepụta ihe microelectronics, agba na pigmenti, ụlọ ọrụ mmepụta ihe na ụlọ ihicha ụlọ;usoro ugbo na ọgwụ |
| Na-eji | N-Methyl-2-pyrrolidone, bara uru maka spectrophotometry, chromatography na nchọpụta ICP-MS. |
| Nkọwa | ChEBI: Onye otu klas nke pyrrolidine-2-nke bụ pyrrolidin-2-otu nke hydrogen jikọtara na nitrogen na-anọchi anya otu methyl. |
| Ụzọ mmepụta | Emepụtara N-Methyl-2-pyrrolidone site na mmeghachi omume buytrolactone na methylamine (Hawley 1977).Usoro ndị ọzọ gụnyere nkwadebe site na hydrogenation nke ngwọta nke maleic acid ma ọ bụ succinic na methylamine (Hort na Anderson 1982).Ndị na-emepụta kemịkalụ a gụnyere Lachat Chemical, Inc, Mequon, Wisconsin na GAF Corporation, Covert City, California. |
| Ntuziaka(s) Synthesis | Akwụkwọ ozi Tetrahedron, 24, p.1323, 1983DOI: 10.1016/S0040-4039(00)81646-9 |
| Nkọwa zuru oke | N-Methyl-2-Pyrrolidone (NMP) bụ ihe mgbaze dị ike, aprotic nwere nnukwu ihe mgbaze, yana obere mgbanwe.Nke a na-enweghị agba, isi mmiri dị elu, ebe ọkụ dị elu na mmiri ikuku dị ala na-ebu isi ísì dị nro.NMP nwere kemịkalụ dị elu na nkwụsi ike na-ekpo ọkụ yana mmiri na-emebi kpamkpam na okpomọkụ niile.NMP nwere ike rụọ ọrụ dị ka ihe mgbaze na mmiri, alcohols, glycol ethers, ketones, na aromatic/chlorinated hydrocarbons.NMP nwere ike megharia ya site na ntughari na ngwa ngwa nke nwere ike imebi ya.Achọghị NMP na listi mmetọ ikuku dị ize ndụ (HAPs) nke ndezigharị iwu ikuku dị ọcha nke 1990. |
| Mmeghachi omume ikuku & mmiri | Soluble na mmiri. |
| Profaịlụ mmeghachi omume | Amine a bụ ntọala kemịkalụ dị nro.N-Methyl-2-pyrrolidone na-emekarị ka ọ ghara imebi acid ka ọ bụrụ nnu na mmiri.Ọnụọgụ okpomọkụ nke a na-emepụta kwa mole nke amine na nkwụsịtụ na-adaberekarị na ike nke amine dịka ntọala.Amines nwere ike ekwekọghị na isocyanates, halogenated organics, peroxides, phenols (acid), epoxides, anhydrides, na acid halides.Amine na-emepụta hydrogen gaseous na-enwu ọkụ yana ngwakọta na-ebelata ihe ndị siri ike, dị ka hydrides. |
| Hazard | Akpụkpọ anụ siri ike na anya mgbakasị ahụ.Ihe mgbawa-ya 2.2-12.2%. |
| Ihe ize ndụ ahụike | Ikuku ikuku na-ekpo ọkụ nwere ike ịkpasu imi na akpịrị.Iri nri na-ebute mgbakasị nke ọnụ na afọ.Ilekọta anya na-akpata mgbakasị ahụ.Mmekọahụ anụ ahụ ugboro ugboro na ogologo oge na-ebute iwe dị nro, na-adịte aka. |
| Ihe ize ndụ ọkụ | Ihe egwu pụrụ iche nke ngwaahịa combustion: Enwere ike ịmepụta oxides nitrogen n'ọkụ. |
| Ịkụ ọkụ na mpụpụ | Enweghị ọkụ |
| Eji ụlọ ọrụ mmepụta ihe | 1) A na-eji N-Methyl-2-pyrrolidone mee ihe dị ka ihe mgbaze dipolar aprotic n'ozuzu, kwụsiri ike ma na-adịghị arụ ọrụ; 2) maka mmịpụta nke hydrocarbons aromatic sitere na mmanụ lubricating; 3) maka iwepụ carbon dioxide na amonia generators; 4) dị ka ihe mgbaze maka mmeghachi omume polymerization na polymers; 5) dị ka agba agba; 6) maka usoro ọgwụ pesticide (USEPA 1985). Ojiji ndị ọzọ na-abụghị ụlọ ọrụ nke N-Methyl-2-pyrrolidone dabeere na ihe onwunwe ya dị ka ihe mgbaze na-ekewapụ adabara maka ọmụmụ ihe electrochemical na anụ ahụ (Langan and Salman 1987).Ngwa ọgwụ na-eji ihe onwunwe nke N-Methyl-2-pyrrolidone dị ka ntinye ntinye maka nnyefe ngwa ngwa nke ihe site na akpụkpọ ahụ (Kydoniieus 1987; Barry na Bennett 1987; Akhter na Barry 1987).N-Methyl-2-pyrrolidone ka akwadoro dị ka ihe mgbaze maka ngwa slimicide na ihe nkwakọ nri (USDA 1986). |
| Kpọtụrụ ndị allergens | N-Methyl-2-pyrrolidone bụ ihe mgbaze aprotic nwere ngwa dị iche iche: nhazi petrochemical, mkpuchi elu, akwa na pigmenti, ogige ihicha ụlọ na ụlọ, yana usoro ọrụ ugbo na ọgwụ.Ọ na-abụkarị ihe mgbakasị ahụ, mana ọ nwere ike ịkpata dermatitis kọntaktị siri ike n'ihi kọntaktị ogologo oge. |
| Profaịlụ nchekwa | Nsi site na eriri afọ.Na-egbu egbu dị ntakịrị site na ntinye na ụzọ intraperitoneal.Eji nwayọọ na-egbu egbu site na kọntaktị akpụkpọ.Teratogen nnwale.Mmetụta ọmụmụ nwale.Akọpụtara data mgbanwe.Na-ere ọkụ mgbe ekpughere ya na okpomọkụ, ọkụ mepere emepe, ma ọ bụ oxidizers siri ike.Iji luso ọkụ ọgụ, jiri ụfụfụ, CO2, kemịkalụ kpọrọ nkụ.Mgbe ọ na-ekpo ọkụ ka ire ere, ọ na-ewepụta uzuzu na-egbu egbu nke NOx. |
| Ọrịa carcinogenicity | Ekpughere oke na N-Methyl-2-pyrrolidone vapor na 0, 0.04, ma ọ bụ 0.4 mg / L maka 6 h / ụbọchị, 5 ụbọchị / izu maka afọ 2. Ụmụ oke nwoke na 0.4 mg / L gosipụtara ntakịrị ihe dị arọ nke ahụ.Enweghị mmetụta na-egbu egbu ma ọ bụ carcinogenic na-ebelata ndụ na oke ekpughere maka afọ 2 ma ọ bụ 0.04 ma ọ bụ 0.4mg / L nke N-Methyl-2-pyrrolidone.Site n'okporo ụzọ dermal, otu ụmụ oke 32 nwetara ntinye mmalite nke 25mg nke N-Methyl-2-pyrrolidone na-esote izu 2 ka e mesịrị site na ngwa nke tumor promoter phorbol myristate acetate, ugboro atọ n'izu, maka ihe karịrị izu 25.Dimethylcarbamoyl chloride na dimethylbenzanthracene jere ozi dị ka njikwa dị mma.Ọ bụ ezie na otu N-Methyl-2-pyrrolidone nwere etuto akpụkpọ anụ atọ, a naghị ele nzaghachi a anya dị ka ihe dị mkpa ma e jiri ya tụnyere nke njikwa dị mma. |
| Metabolic ụzọ | A na-enye oke oke redio nke akpọrọ N-methyl-2-pyrrolidinone (NMP), na ụzọ bụ isi nke oke na-esi ewepụ bụ site na mmamịrị.Isi metabolite, na-anọchite anya 70-75% nke ọgwụ a na-enye, bụ 4- (methylamino) butenoic acid.Enwere ike ịmepụta ngwaahịa a na-adịghị mma site na mkpochapụ mmiri, na otu hydroxyl nwere ike ịdị na metabolite tupu acid hydrolysis. |
| Metabolism | Enyere ụmụ oke Sprague-Dawley otu ịgba ọgwụ intraperitoneal (45 mg / kg) nke radiolabeled 1 -methyl-2-pyrrolidone.A na-enyocha ọkwa plasma nke redioaktivu na ngwakọta maka awa isii yana nsonaazụ tụrụ aro ka usoro nkesa ngwa ngwa bụ nke na-esochi usoro mkpochapụ ngwa ngwa.E wepụrụ nnukwu akara akara n'ime mmamịrị n'ime awa 12 wee gbakọọ ihe dịka 75% nke ọgwụ akara.Mgbe awa iri abụọ na anọ gachara ọgwụ ahụ, mkpokọ mkpokọ (mmamiri) bụ ihe dịka 80% nke dose ahụ.A na-eji ụdị mgbanaka abụọ na methyl labeled mee ihe, yana ha abụọ.14C] - na [3H] -akpọrọ l-methyl-2-pyrrolidone.A na-edobe oke akara izizi n'ime awa 6 mbụ ka usoro ọgwụgwọ ahụ gasịrị.Mgbe awa 6 gachara, a chọpụtara na imeju na eriri afọ nwere mkpokọta redioactivity kacha elu, ihe dịka 2-4% nke dose ahụ.Achọpụtara obere ọrụ redio na bile ma ọ bụ ikuku iku ume.Igwe mmiri chromatography nke mmamịrị dị elu gosipụtara ọnụnọ nke otu isi na obere metabolites abụọ.A na-enyocha isi metabolite (70-75% nke usoro ọgwụgwọ redioaktivu) site na mmiri chromatography-mass spectrometry na gas chromatography-mass spectrometry wee tụọ ya ka ọ bụrụ 3- ma ọ bụ 5-hydroxy-l-methyl-2-pyrrolidone (Wells). 1987). |
| Ụzọ nke ịdị ọcha | Ghichaa pyrrolidone site na iwepu mmiri dị ka * benzene azeotrope.Nkebi nkebi gbasa na 10 torr site na kọlụm 100-cm nke jupụtara na helice iko.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] The hydrochloride nwere m 86-88o (si EtOH ma ọ bụ Me2CO/EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III/IV 3145, 21/6 V 321.] |
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